![]() ![]() ![]() Whether the blood hyperviscosity and decreased RBC deformability are responsible for these complications is unknown. Of note, 2 out of 7 CC developed retinopathy or otologic disorders. In contrast, all of them had splenomegaly. Despite these hemorheological abnormalities, CC never had hospitalized painful vaso-occlusive crisis or acute chest syndrome. RBC aggregation abnormalities were observed in CC: low RBC aggregation index and high RBC aggregates strength. The CC group exhibited very rigid hyperchromic RBC compared to the three other groups. Nevertheless, HVR was higher in CC compared to SS and tended to be higher than in SC. CC and SC had higher blood viscosity and lower HVR than AA. RBC deformability was determined at 30 Pa by ektacytometry, and RBC aggregation properties by syllectometry. an index of red blood cell (RBC) oxygen transport effectiveness, was calculated. The hematocrit-to-blood viscosity ratio (HVR), i.e. Blood viscosity was measured at 225 s(-1) with a cone plate viscometer. The present study compared the hematological, biochemical, hemorheological and clinical characteristics of CC patients to those of SS, SC and healthy individuals (AA). Patients with hemoglobin C disease (CC) usually do not develop severe complications in comparison with individuals with sickle cell anemia (SS) or with sickle cell hemoglobin C disease (SC). ![]()
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